Seems like the biggest benefit is for high-end applications only:
Most Windows users, however, don't really care what happens beyond 1Gbps, and
this is where things get interesting. Windows users with an Ethernet
connection generally haven't had much trouble getting close to 1Gbps or so
with the old slow wireguard-go/Wintun, but over WiFi, those same users would
commonly see massive slowdowns. With the significantly decreased latency of
WireGuardNT, it appears that these slowdowns are no more. Jonathan Tooker
reported to me that, on his system with an Intel AC9560 WiFi card, he gets
600Mbps without WireGuard, 600Mbps with wireguard-go/Wintun over Ethernet,
95Mbps with wireguard-go/Wintun over WiFi, and 600Mbps with WireGuardNT over
WiFi. In other words, the WiFi performance hit from wireguard-go/Wintun has
evaporated when using WireGuardNT. Power consumption, and hence battery usage,
should be lower too.
Less power consumption sounds nice for everyone though. Wireguard is already really efficient compared to openvpn.